The basic structure of cubosomes includes honeycombed structures separating the two internal aqueous channels along with large interfacial area. Now a days the self assembled cubosomes applications as the drug delivery system is attracting great attention since its discovery. The cubosomes generally have different internal cubic structure along with variant composition related to the drug loading modalities. The cubosomes have huge potential in drug nano formulations for melanoma therapy due to their potential advantages consisting high drug payloads. The cubosomes having high internal surface area along with cubic crystalline structures and also exhibit several potential advantages like simple preparation method, biodegradability of lipids, the ability of encapsulating hydrophobic, hydrophilic, amphiphilic substances, targeting along with controlled release of bioactive agents. The preparation of cubosomes mostly involves simple emulsification of monoglycerides along with a polymer accompanied via sonication and homogenization. There are two different method are available for preparation of cubosomes includes top-down and bottom-up techniques.
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